Anna Maria NiewiadomskaI have over 10 years of experience in basic science research. My track record includes experience Dr. Eckard Wimmer (Stony Brook University), in whose lab the first biochemical synthesis of a virus took place. I then moved to the lab of Dr. Richard O. Hynes (Koch Institute for Integrative Cancer Research, MIT) where I learned a variety of cell biology techniques while researching metastasis and cell adhesion. My PhD studies were completed in the lab of Dr. Xiao-Fang Yu (Johns Hopkins Bloomberg School of Public Health), where research was focused on retroviral accessory proteins, and cellular restriction factors of retroviruses. I showed that in addition to inhibiting HIV, the anti-retroviral APOBEC3 proteins were capable of inhibiting endogenous retroelement replication, and studied the mechanisms by which they restricted human LINE-1 elements. I continued this work as a post-doc in the lab of Dr. Jef Boeke (Johns Hopkins School of Medicine), where biochemical synthesis of the first eukaryotic cell genome is currently ongoing. Since then I have been working as a post-doc with Dr. Robert Gifford, performing field and laboratory research, and linking this research to the bioinformatic actives in the lab.
PublicationsNiewiadomska AM and RJ Gifford (2013) The extraordinary evolutionary history of the reticuloendotheliosis viruses. PLoS Biology 11 (8): e1001642 [view]
An W, Dai L, Niewiadomska AM, Yetil A, O'Donnell KA, Han JS, Boeke JD. (2011) Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs. Mob DNA. 2(1):2. doi: 10.1186/1759-8753-2-2. [view]
Niewiadomska AM, Yu XF. (2009) Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif. Curr Top Microbiol Immunol. 339:1-25. doi: 10.1007/978-3-642-02175-6_1. [view]
Zhang W, Chen G, Niewiadomska AM, Xu R, Yu XF. (2008) Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins. PLoS One 3(12):e3963. doi: 10.1371/journal.pone.0003963. Epub 2008 Dec 17. [view]
Ehrlich ES, Wang T, Luo K, Xiao Z, Niewiadomska AM, Martinez T, Xu W, Neckers L, Yu XF. (2009) Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase. PNAS 106(48):20330-5. [view]
Niewiadomska AM, Tian C, Tan L, Wang T, Sarkis PT, Yu XF. (2007) Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association. J. Virol. 81(17):9577-83. [view]